Motivation Expertise in biomaterial research requires a profound understanding of cellular behaviour, especially in the context of the various external environments. Cells produce many useful biomolecules, including complex types of extracellular matrix (ECM), some of which, such as hyaluronan, collagen and others, have already been successfully commercialized. At the same time, recent research indicates that cell-material interactions have a significant impact on cellular behaviour, including changes in cell metabolism, signalling, gene expression patterns and even cell identity. Hence, advanced knowledge of molecular and cell biology is the key to the rational design of both innovative biomaterials as well as for the creation of synthetic artificial materials intended to interact with living matter. Objectives The objective of the course is to provide students with the knowledge of contemporary and cutting-edge comprehension of cellular functions and interactions on a molecular scale. The initial segment of the course will delve into key intracellular processes, followed by an examination of cellular behaviour and interplay within tissues. The later lectures will deepen the discussion to encompass the realm of reciprocal cellular interactions with the external environment, encompassing a special emphasis on novel materials, which will be a central focal point of this course. By successfully completing this course, students will acquire a comprehensive set of skills and knowledge at the forefront of cellular and molecular biology, empowering them to excel in the dynamic field of biomaterial research and development. Profound understanding of cellular behaviour. Students will develop a nuanced understanding of how cells function at the molecular level and will be able to critically analyse the molecular mechanisms that drive cellular responses. Cellular-tissue interactions. Students will understand how cells collaborate within tissues. They will also gain insights into the complex network of biomolecules that contribute to the structural integrity and functionality of tissues. Insight into cell-material interactions. Students will get familiar with the critical nexus of cell-material interactions, comprehending their profound influence on cellular behaviour and identity. This knowledge will equip students with the tools to design and engineer innovative biomaterials that elicit specific cellular responses, contributing to advancements in medical devices, regenerative medicine, and tissue engineering. Integration of multidisciplinary knowledge. Students will develop the ability to integrate knowledge from various fields, including biology, chemistry, and materials science. They will be able to assess complex biological processes, dissect intricate molecular pathways, and evaluate the potential impact of synthetic materials on cellular behaviour. Application of cutting-edge research. By engaging with recent advancements in the field, students will learn to apply the latest research findings to real-world scenarios. This will enable students to contribute to the development of groundbreaking biomaterials and their implementation in diverse biomedical contexts. Overall, this course will provide students with a comprehensive toolkit of skills and knowledge essential for a successful career in biomaterial research. The practical part of the course will cover practical aspects of the theoretical topics - Cell cycle assays - Cellular metabolism and death assays - Cell migration assays - Formation of an epithelial sheet, cellular growth in 3-D. The theoretical part of the course will cover the following topics 1. Composition of the cell 2. Key cellular processes 3. Tissues 4. Interactions of cells with the external environment 5. Advances in regulation of cellular responses by materials. The mentioned topics are specified in more detail in the weblink.
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