Motivation The Institute of Biomedicine and Laboratory Diagnostics of the Faculty of Health Studies of J. E. Purkyne University and Masaryk Hospital in Ústí nad Labem includes the Department of Clinical Biochemistry, the Department of Laboratory Immunology and the Biomedical Centre. The modern equipment of all these departments provides a wide range of possibilities for studying the influence of various environmental factors, implants, new biomedical materials and their surfaces on the human organism. Objectives The Department of Clinical Biochemistry allows monitoring of many parameters in various body fluids, especially blood and urine. An example is the study of the influence of stress hormone levels on the level of biochemical parameters of homeostasis. The laboratory can provide expert and technical support for various topics. However, the relevant steps are always performed after they have been specified. The Department of Laboratory Immunology provides a wide portfolio of measurements of various immunological parameters. The expected topics of study are the influence of environmental conditions on the manifestations of allergic, autoimmune or lymphoproliferative diseases. Details will also be addressed in accordance with the dissertation assignment. The Biomedical Centre specializes in the analysis of various extravascular body fluids, including cerebrospinal fluid, intraocular fluid, pleural effusions, abdominal effusions, pericardial effusions, peritoneal fluid, synovial fluid, etc. The Institute of Biomedicine and Laboratory Diagnostics in cooperation with the Clinic of Neurosurgery of the Faculty of Health Studies of J. E. Purkinje University and Masaryk Hospital in Ústí nad Labem enables studies focused on the detection of titanium in body fluids of patients with titanium implants and testing its toxicity. Another possibility is to study the application of nanomaterials on the surface structures of implants. The detail laboratory tests and practical exercises will be specified based on students needs, more specifically, related to the topic of dissertation thesis. Acquired skills and knowledge After finishing the course, students will be familiar with immunological and/or biomedical testing relevant to their research topic. They should understand the relationship and correlation between materials, devices, technologies etc. being developed and their consequent testing in clinical and biomedical environments. Thus, they should have gained proficiency in designing biomaterials by already considering their future use in the medical environment. Students should also become familiar with medical terminology, therefore, being able to faster transfer laboratory examples into clinical studies. Students will become familiar with a biohazard working environment. Literature: 1. B. Alberts, R. Heald, K. Hopkin, A. Johnson, D. Morgan, K. Roberts, P. Walter. Essential Cell Biology, WW Norton & Company, (2023). 2. A. K. Abbas, A. H. Lichtman, S. Pillai. Basic Immunology, 7th Ed., Elsevier, (2023). 3. D. Male, R. S. Peebles, V. Male, Immunology, 9th Ed., Elsevier, (2020). 4. P. J. Delves, S. J. Martin, D. R. Burton, I. M. Roitt, Roitt's Essential Immunology (Essentials), 13th Ed., Wiley-Blackwell, (2016). 5. P. J. Kennelly, K. M. Botham, O. McGuinness, V. W. Rodwell, P. A. Weil, Harper's Illustrated Biochemistry, 32nd Ed., McGraw Hill/Medical, (2000).
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