Course: Biochemistry

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Course title Biochemistry
Course code KECHT/1BICH
Organizational form of instruction Lecture + Lesson
Level of course Master
Year of study 1
Semester Winter and summer
Number of ECTS credits 2
Language of instruction Czech
Status of course Compulsory
Form of instruction unspecified
Work placements unspecified
Recommended optional programme components None
Lecturer(s)
  • Trögl Josef, doc. Ing. Ph.D.
  • Nguyen Thi Thu Huong, RNDr. Ph.D.
Course content
1. Contents of biochemistry - stages of evolution, characteristics of alive matter, constitution of alive systems 2. Common pathways of biochemical metabolism - catabolism and anabolism, citrate ( Krebs) cycle, glycolytic pathways 3. Bioenergetics - macroergic substrates , ATP, respiration chain, oxygen phosphorylation, photosynthesis ( light harvesting complex, photosystems , Calvin cycle ) 4. Monosaccharides - stereochemistry, physical and chemical characteristics of monosascharides, derivatives of monosaccharides, catabolic pathways of glucose ( glycolysis, pentose cycle, gluconeogenesis, Cori cycle ), interconversion of monosaccharides ( metabolism of fructose, galactose, mannose ) 5. Oligosaccharides and polysaccharides - characteristics of disaccharides and polysaccharides ( nomenclature, physical and chemical characters ) glycogenolysis and glycogenesis, heteropolysaccharides, biological mean of glycosaminoglycans and glycoproteins 6. Lipids - definition, biological functions, nomenclature, catabolisms of fatty acids ( ß-oxidation pathway ), biosynthesis of fatty acids, triglycerides, glycerophospholipids biosynthesis of cholesterol, metabolism of lipoproteins , regulation of lipids metabolism 7. Aminoacids - physical and chemical characteristics, hereditary defects of the metabolic pathways of aminoacids, L-tyrosine as a precursor of biosynthesis of catecholamines, hormones of thyroid glands, biosynthesis of heme, creatin, ornithin ( ureosynthetic ) cycle 8. Proteins - classification of proteins, conformation of proteins with their biological function , denaturation and digestion of proteins. 9. Enzymes - nomenclature and terminology of enzymes, isoenzymes, catalytic activity of enzymes, mean and functions of the active centre, view of cofactors and vitamins, kinetic of enzymatic reactions, equation Michaelis and Menten, types of inhibitors of enzymatic reactions, regulation of metabolisms on the level of cells. 10. Hormones - regulation of organ functions and metabolic processes of the nervous system, principle actions of hydrofobic and lipophylic hormones, hormones of hypothalamus, glandotropic hormones, steroid hormones and steroid biosynthesis, sexual hormones, exocrine and endocrine pancreatic functions, tissue hormones, hormonal regulation of metabolism of glucose calcium and minerals. 11. Nucleic acids - structural and functional types of DNA and RNA, purine and pyrimidine bases , the formations of complementary base pairs, genetic code, replication and transcription of DNA, regulation of transcription, translation ( proteosynthesis), posttranslation modifications 12. Xenobiochemistry - the fate of xenobiotics in the organism - biotransformation, principle basics of catabolism of xenobiotics, 13. Biological membranes - structure and characteristics of biomembranes, type of membrane transports 14. Physiological biochemistry - connnection between physiological and biochemical processes, role of reactive oxygen species ( ROS ) and antioxidative systems in organism

Learning activities and teaching methods
unspecified
Recommended literature
  • Dostál J., Pavlová H., Slanina J., Táborská E. Biochemie pro bakaláře, LF MU Brno, 2003. 2003.
  • Duchoň J. a kol. Lékařská chemie a biochemie, Avicenum Praha, 1985. 1985.
  • Horák P. Základy biochemie biotechnologických procesů v ochraně životního prostředí, FŽP UJEP, Ústí nad Labem 2006. Ústí nad Labem, 2006.
  • Horák V., Stazskova L. Biochemie, Fakulta agronomická ČZU, Praha 2002. Praha, 2002.
  • Kalousová M. Patobiochemie ve schématech, Grada, Avicenum, 2006. 2006.
  • Klouda P. Základy biochemie, Ostrava 2000. Ostrava, 2000.
  • Kodíček M. Biochemické pojmy - výkladový slovník,VŠCHT Praha, 2004. Praha, 2004.
  • Kolektiv autorů. Biochemie - základní kurs, Karolinum Praha, 1999. Praha, 1999.
  • Ledvina M. Biochemie, Gaudeamus Hradec Králové, 1998. 1998.
  • Ledvina M.,Stoklasová A.,Cerman J. Biochemie pro studující mediciny I.,II.díl, UK Praha, 2004. Praha, 2004.
  • Murray R.K, Granner D.K., Mayes P.A.,Rodwell V.W. Harperova biochemie, H&H Praha, 1998. Praha, 1998.
  • Musil J.,Nováková O. Biochemie v obrazech a schématech , Avicenum Praha, 1990. Praha, 1990.
  • Odstrčil J. Biochemie, 1995. 1995.
  • Pavel J. Biochemie, SPN, Praha 1989. Praha, 1989.
  • Skálová L., Szotáková B., Netopilová M. Základní biochemické dráhy v buňce, UK Praha, 2004. Praha, 2004.
  • Šípal Z. a kol. Biochemie, SPN Praha, 1992. 1992.
  • ŠTERN P. Obecná a klinická biochemie, Karolinum, Praha 2011. ISBN: 978-80-246-1979-8.. Praha, 2005.
  • Tomandl S., Táborská E. Semináře z biochemie II , LF MU Brno, 1998. 1998.
  • Vodrážka Z. Biochemie, Academia Praha, 1999. Praha, 1999.
  • Voet D., Voetová J. Biochemie, Victoria Publishing Praha, 1995. Praha, 1995.
  • Zehnálek J. Biochemie, Mendelova zemědělská a lesnická fakulta ,Brno 2001. Brno, 2001.


Study plans that include the course
Faculty Study plan (Version) Category of Branch/Specialization Recommended year of study Recommended semester
Faculty: Faculty of Environment Study plan (Version): Waste Management (C_3) Category: Ecology and environmental protection 1 Recommended year of study:1, Recommended semester: Summer