The central topic of the lecture is the processes that take place when biomaterials are contacted by biological systems. Both the causes, the potential biological consequences and in particular the possibilities of influence through surface design on such interfacial processes are dealt with. The relevant foundations of cell communication and cell reaction to biochemical and physical properties are also considered against this background. Various methods of defined design of biomaterial surfaces are explained with particular attention (i) of biological backgrounds, (ii) methods for generating surface states, (iii) the surface properties to be sought and (iv) the cell biological, animal and clinical results. This includes: ? the production of defined morphologies by physical and chemical processes, ? physical/chemical modification of surface properties, ? inorganic coating systems as well as ? the field of BioSurface Engineering, i.e. the biomimetic replica of the native cell environment provided by the extracellular matrix (ECM). In the latter, the possible uses of various components of the native ECM, (peptides, (structure) proteins, growth factors, glycosaminoglycans, nucleic acids, aptamers) for BioSurface engineering are presented and, depending on substrates and components, the advantages and disadvantages of immobilization strategies are comprehensively presented. This is discussed with examples from the current research of the Chair. This course was created as part of the project "MATun" - Materialwissen - Unis gemeinsam
|